β‐escin sodium suppressed phosphorylation and nuclear translocation of STAT1 (Tyr701) and STAT3 (Tyr705) induced by CM but did not affect the activation of c‐Jun and NF‐κB. ![]() β‐escin sodium (5–40 µg/mL) inhibited cytokine mixture (CM)‐induced nitric oxide (NO) production in A549 cells by reducing the expression of iNOS. In the present study, we investigated its effect on cell proliferation and inducible nitric‐oxide synthase (iNOS) expression in human lung carcinoma A549 cells. Previous work has found that β‐escin sodium has antiinflammatory and antitumor effects. Β‐escin, a triterpene saponin, is one of the major active compounds extracted from horse chestnut ( Aesculus hippocastanum) seed. ![]() 10.1254/ are often used for varicose veins, varicocele, and erectile dysfunction. Possible Mechanism of the Anti-inflammatory Activity of Ruscogenin: Role of Intercellular Adhesion Molecule1 and Nuclear Factor-κB.
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